Upregulation of Urinary L-FABP in Chronic Kidney Disease Progression with Proton Pump Inhibitors : A Case-control Study

พญ. ศรินภา อุปริมาตร์ ได้รับรางวัล ในงานประกวดวิจัยราชวิทยาลัยอายุรแพทย์ ปี 2562

Proton pump inhibitors (PPIs) increases risk of progression of chronic kidney disease (CKD) possibly due to tubulointerstitial nephritis. However, sparse data are demonstrated the evidence of tubulointerstitial damage. A novel biomarker of structural changes in tubular cells such as liver-type fatty acid binding protein (L-FABP), is used as a predictor of CKD progression by some researchers. We hypothesized that changing of urinary L-FABP due to interstitial fibrosis can predict the progression of CKD in patients with prolong used of PPIs.